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INAPPROPRIATE SINUS TACHYCARDIA (IST)

What is Inappropriate Sinus Tachycardia?

  • IST is a form of dysautonomia (dysfunction of the autonomic nervous system) that is estimated to impact around 1.2% of the population.
  • It is defined as a sinus heart rate over 100 bpm at rest, with an average heart rate of over 90bpm over 24 hours. A person with IST may also have an exaggerated heart rate response to minimal activity, like when going from lying to standing, and at times may have an overlapping diagnosis with postural orthostatic tachycardia syndrome (POTS).
  • The mechanisms leading to IST are unfortunately not completely understood.

Clinical Features and Diagnosis

IST Symptoms

Patients with IST range in presentation from asymptomatic to complaining of extremely debilitating symptoms such as palpitations, weakness, chest pain, shortness of breath, fatigue, dizziness, or near syncope.

Diagnosing IST

IST is a diagnosis of exclusion. If IST is suspected, a thorough medical history review and physical examination should be performed to rule out secondary causes for the tachycardia.

Workup will often consist of some of the following: EKG, heart monitoring, an echocardiogram, a stress test, lab work, a tilt table test, and/or autonomic function testing.

IST Pathophysiology

The mechanisms leading to IST are not completely understood, but several underlying pathologies can result in this syndrome, including increased sinus node automaticity, beta-adrenergic hypersensitivity, decreased parasympathetic activity, and impaired neurohumoral modulation.

  • Beta-adrenergic receptor antibodies can sensitize beta-adrenergic receptors in some patients, while other patients might have increased sympathetic activity and sensitivity, with or without inherent impaired sinus node automaticity. Other mechanisms include muscarinic2 receptor hyposensitivity, abnormal baroreflex activity, and regional autonomic dysregulation. In some patients with IST similar to POTS, some researchers have noted evidence of length-dependent autonomic neuropathy, excessive venous pooling, beta-adrenergic receptor hypersensitivity, alpha-adrenergic receptor hyposensitivity, altered sympathovagal balance, and brain stem dysregulation.

Treatment for IST

  • There are very few pharmacological treatments with solid evidence for IST patients, and currently, there are no long-term trials on any therapeutic intervention that has demonstrated a substantial improvement in outcomes.
  • Medications for IST, which may include beta-blockers, calcium channel blockers, Florinef, midodrine, and Corlanor take a lot of trial and error, with treatment aimed at reducing the heart rate and improving symptoms.
  • Unfortunately, symptoms can continue in some patients despite improved heart rate control.
  • Treatment with non-medication modalities is exceedingly important and may include increasing fluid and sodium intake, wearing compression stockings, and doing a regimented exercise program.

IST Prognosis

The prognosis of IST is not clearly understood yet. The risk of tachycardia-induced cardiomyopathy is largely unknown and thought to be very low, only reported in isolated case reports. There is little information on the long-term outcomes of this condition, although there is no known mortality. IST is believed to be a chronic condition.

  • Untreated IST has been suggested to be a predisposing factor to the development of systemic hypertension.
  • Adequate management of IST remains a major challenge for physicians and patients alike. Most systemic symptoms seem to persist despite HR slowing by using different treatment options as outlined above, so a multidisciplinary approach involving pharmacotherapy along with catheter ablation to modify the sinus node in select cases, as well as treatment of any associated behavioral and psychological disorders, physical conditioning, and lifestyle modification, is essential.

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